Quality of Life

    Last Updated: September 11, 2019

    Quality of life (QOL) refers to a general, all concompassing, response as to how tolerance and enjoyable one's living conditions are. QOL is impaired in various disease states that reduce functionality or cause pain, and treating these symptoms causes an increase in QOL.

    examine-databaseExamine Database
    12,741 participants in 46 trials

    Examine Database: Quality of Life

    Low-FODMAP Diet
    B
    Mixed effect
    Coenzyme Q10
    B
    Small Improvement
    Autoimmune Protocol (AIP) Diet
    B
    Small Improvement
    Kefir
    Magnesium
    Iron
    Cannabis
    DHEA
    Saw Palmetto
    Yarrow
    Specific Carbohydrate Diet (SCD)
    Mediterranean Diet
    Panax Ginseng (Korean Ginseng)
    Curcumin
    Ashwagandha
    Resveratrol
    Berberine
    Oxiracetam
    Melatonin
    Fish Oil
    Lavender
    Garlic
    Maca
    N-Acetylcysteine
    L-Carnitine
    Creatine
    Probiotics
    Elderberry
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    Examine Database References

    1. Low-FODMAP Diet - Natalia Pedersen, Nynne Nyboe Andersen, Zsuzsanna Végh, Lisbeth Jensen, Dorit Vedel Ankersen, Maria Felding, Mette Hestetun Simonsen, Johan Burisch, Pia MunkholmEhealth: low FODMAP diet vs Lactobacillus rhamnosus GG in irritable bowel syndromeWorld J Gastroenterol.(2014 Nov 21)
    2. Coenzyme Q10 - Lee YJ, Cho WJ, Kim JK, Lee DCEffects of coenzyme Q10 on arterial stiffness, metabolic parameters, and fatigue in obese subjects: a double-blind randomized controlled studyJ Med Food.(2011 Apr)
    3. Low-FODMAP Diet - Selina R Cox, James O Lindsay, Sébastien Fromentin, Andrew J Stagg, Neil E McCarthy, Nathalie Galleron, Samar B Ibraim, Hugo Roume, Florence Levenez, Nicolas Pons, Nicolas Maziers, Miranda C Lomer, S Dusko Ehrlich, Peter M Irving, Kevin WhelanEffects of Low FODMAP Diet on Symptoms, Fecal Microbiome, and Markers of Inflammation in Patients With Quiescent Inflammatory Bowel Disease in a Randomized TrialGastroenterology.(2020 Jan)
    4. Low-FODMAP Diet - Leda Roncoroni, Karla A Bascuñán, Luisa Doneda, Alice Scricciolo, Vincenza Lombardo, Federica Branchi, Francesca Ferretti, Bernardo Dell'Osso, Valeria Montanari, Maria Teresa Bardella, Luca ElliA Low FODMAP Gluten-Free Diet Improves Functional Gastrointestinal Disorders and Overall Mental Health of Celiac Disease Patients: A Randomized Controlled TrialNutrients.(2018 Aug 4)
    5. Saw Palmetto - Suter A, Saller R, Riedi E, Heinrich MImproving BPH symptoms and sexual dysfunctions with a saw palmetto preparation? Results from a pilot trialPhytother Res.(2013 Feb)
    6. Low-FODMAP Diet - Giorgia Bodini, Claudia Zanella, Mattia Crespi, Sara Lo Pumo, Maria Giulia Demarzo, Edoardo Savarino, Vincenzo Savarino, Edoardo G GianniniA randomized, 6-wk trial of a low FODMAP diet in patients with inflammatory bowel diseaseNutrition.(Nov-Dec 2019)
    7. Kefir - Peter Smoak, Nicholas Harman, Victoria Flores, Jacob Kisiolek, Nicholas A Pullen, Jonathan Lisano, Reid Hayward, Laura K StewartKefir Is a Viable Exercise Recovery Beverage for Cancer Survivors Enrolled in a Structured Exercise ProgramMed Sci Sports Exerc.(2021 Oct 1)
    8. Cannabis - Gil Bar-Sela, Daniela Zalman, Valerya Semenysty, Eyal BallanThe Effects of Dosage-Controlled Cannabis Capsules on Cancer-Related Cachexia and Anorexia Syndrome in Advanced Cancer Patients: Pilot StudyIntegr Cancer Ther.(Jan-Dec 2019)
    9. DHEA - Axel Finckh, Isabelle Carey Berner, Bérengère Aubry-Rozier, Alexander Kai-Lik SoA randomized controlled trial of dehydroepiandrosterone in postmenopausal women with fibromyalgiaJ Rheumatol.(2005 Jul)
    10. Autoimmune Protocol (AIP) Diet - Robert D Abbott, Adam Sadowski, Angela G AltEfficacy of the Autoimmune Protocol Diet as Part of a Multi-disciplinary, Supported Lifestyle Intervention for Hashimoto's ThyroiditisCureus.(2019 Apr 27)
    11. Low-FODMAP Diet - Ruth M Harvie, Alexandra W Chisholm, Jordan E Bisanz, Jeremy P Burton, Peter Herbison, Kim Schultz, Michael SchultzLong-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPsWorld J Gastroenterol.(2017 Jul 7)
    12. Ashwagandha - Choudhary B, Shetty A, Langade DGEfficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adultsAyu.(2015 Jan-Mar)
    13. Low-FODMAP Diet - Mohammad Javad Zahedi, Vahideh Behrouz, Maryam AzimiLow fermentable oligo-di-mono-saccharides and polyols diet versus general dietary advice in patients with diarrhea-predominant irritable bowel syndrome: A randomized controlled trialJ Gastroenterol Hepatol.(2018 Jun)
    14. Saw Palmetto - Barry MJ, Meleth S, Lee JY, Kreder KJ, Avins AL, Nickel JC, Roehrborn CG, Crawford ED, Foster HE Jr, Kaplan SA, McCullough A, Andriole GL, Naslund MJ, Williams OD, Kusek JW, Meyers CM, Betz JM, Cantor A, McVary KT, Complementary and Alternative Medicine for Urological Symptoms (CAMUS) Study GroupEffect of increasing doses of saw palmetto extract on lower urinary tract symptoms: a randomized trialJAMA.(2011 Sep 28)
    15. Low-FODMAP Diet - Bridgette Wilson, Megan Rossi, Tokuwa Kanno, Gareth C Parkes, Simon Anderson, A James Mason, Peter M Irving, Miranda C Lomer, Kevin Whelanβ-Galactooligosaccharide in Conjunction With Low FODMAP Diet Improves Irritable Bowel Syndrome Symptoms but Reduces Fecal BifidobacteriaAm J Gastroenterol.(2020 Jun)
    16. Oxiracetam - Bottini G, Vallar G, Cappa S, Monza GC, Scarpini E, Baron P, Cheldi A, Scarlato GOxiracetam in dementia: a double-blind, placebo-controlled studyActa Neurol Scand.(1992 Sep)
    17. Kefir - Gulbeyaz Can, Erkan Topuz, Duygu Derin, Zehra Durna, Adnan AydinerEffect of kefir on the quality of life of patients being treated for colorectal cancerOncol Nurs Forum.(2009 Nov)
    18. Creatine - Christiano R R Alves, Bianca M Santiago, Fernanda R Lima, Maria C G Otaduy, Ana Luisa Calich, Aline C C Tritto, Ana Lúcia de Sá Pinto, Hamilton Roschel, Cláudia C Leite, Fabiana B Benatti, Eloisa Bonfá, Bruno GualanoCreatine supplementation in fibromyalgia: a randomized, double-blind, placebo-controlled trialArthritis Care Res (Hoboken).(2013 Sep)
    19. Low-FODMAP Diet - Shanti Eswaran, William D Chey, Kenya Jackson, Sivaram Pillai, Samuel W Chey, Theresa Han-MarkeyA Diet Low in Fermentable Oligo-, Di-, and Monosaccharides and Polyols Improves Quality of Life and Reduces Activity Impairment in Patients With Irritable Bowel Syndrome and DiarrheaClin Gastroenterol Hepatol.(2017 Dec)
    20. Cannabis - Cannabis-In-Cachexia-Study-Group, Strasser F, Luftner D, Possinger K, Ernst G, Ruhstaller T, Meissner W, Ko YD, Schnelle M, Reif M, Cerny TComparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled clinical trial from the Cannabis-In-Cachexia-Study-GroupJ Clin Oncol.(2006 Jul 20)
    21. L-Carnitine - William R Hiatt, Mark A Creager, Antonino Amato, Eric P BrassEffect of propionyl-L-carnitine on a background of monitored exercise in patients with claudication secondary to peripheral artery diseaseJ Cardiopulm Rehabil Prev.(Mar-Apr 2011)
    22. Coenzyme Q10 - K Adarsh, H Kaur, V MohanCoenzyme Q10 (CoQ10) in isolated diastolic heart failure in hypertrophic cardiomyopathy (HCM)Biofactors.(2008)
    23. Panax Ginseng (Korean Ginseng) - Masoud Etemadifar, Farnaz Sayahi, Seyed-Hossein Abtahi, Hamidreza Shemshaki, Gholam-Ali Dorooshi, Mohammad Goodarzi, Mojtaba Akbari, Mahboobeh Fereidan-EsfahaniGinseng in the treatment of fatigue in multiple sclerosis: a randomized, placebo-controlled, double-blind pilot studyInt J Neurosci.(2013 Jul)
    24. Maca - Gonzales-Arimborgo C, Yupanqui I, Montero E, Alarcón-Yaquetto DE, Zevallos-Concha A, Caballero L, Gasco M, Zhao J, Khan IA, Gonzales GFAcceptability, Safety, and Efficacy of Oral Administration of Extracts of Black or Red Maca (Lepidium meyenii) in Adult Human Subjects: A Randomized, Double-Blind, Placebo-Controlled StudyPharmaceuticals (Basel).(2016 Aug 18)
    25. Specific Carbohydrate Diet (SCD) - James D Lewis, Robert Sandler, Carol Brotherton, Colleen Brensinger, Hongzhe Li, Michael D Kappelman, Scott G Daniel, Kyle Bittinger, Lindsey Albenberg, John F Valentine, John Hanson, David Suskind, Andrea Meyer, Charlene W Compher, Meenakshi Bewtra, Akriti Saxena, Angela Dobes, Benjamin Cohen, Ann D Flynn, Monika Fischer, Sumona Saha, Arun Swaminath, Bruce Yacyshyn, Ellen Scherl, Sara Horst, Jeffrey R Curtis, Kimberly Braly, Lisa Nessel, Maureen McCauley, Liam McKeever, Hans Herfarth, DINE-CD Study GroupA Randomized Trial Comparing the Specific Carbohydrate Diet to a Mediterranean Diet in Adults with Crohn's DiseaseGastroenterology.(2021 May 27)
    26. Low-FODMAP Diet - Heidi Maria Staudacher, Miranda C E Lomer, Freda M Farquharson, Petra Louis, Francesca Fava, Elena Franciosi, Matthias Scholz, Kieran M Tuohy, James O Lindsay, Peter M Irving, Kevin WhelanA Diet Low in FODMAPs Reduces Symptoms in Patients With Irritable Bowel Syndrome and A Probiotic Restores Bifidobacterium Species: A Randomized Controlled TrialGastroenterology.(2017 Oct)
    27. Garlic - Ishikawa H, Saeki T, Otani T, Suzuki T, Shimozuma K, Nishino H, Fukuda S, Morimoto KAged garlic extract prevents a decline of NK cell number and activity in patients with advanced cancerJ Nutr.(2006 Mar)
    28. Berberine - Zeng XH, Zeng XJ, Li YYEfficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathyAm J Cardiol.(2003 Jul 15)
    29. Curcumin - Choi YH, Han DH, Kim SW, Kim MJ, Sung HH, Jeon HG, Jeong BC, Seo SI, Jeon SS, Lee HM, Choi HYA randomized, double-blind, placebo-controlled trial to evaluate the role of curcumin in prostate cancer patients with intermittent androgen deprivationProstate.(2019 May)
    30. Coenzyme Q10 - Glover EI, Martin J, Maher A, Thornhill RE, Moran GR, Tarnopolsky MAA randomized trial of coenzyme Q10 in mitochondrial disordersMuscle Nerve.(2010 Nov)
    31. Autoimmune Protocol (AIP) Diet - Anita Chandrasekaran, Shauna Groven, James D Lewis, Susan S Levy, Caroline Diamant, Emily Singh, Gauree Gupta KonijetiAn Autoimmune Protocol Diet Improves Patient-Reported Quality of Life in Inflammatory Bowel DiseaseCrohns Colitis 360.(2019 Oct)
    32. Magnesium - Macian N, Dualé C, Voute M, Leray V, Courrent M, Bodé P, Giron F, Sonneville S, Bernard L, Joanny F, Menard K, Ducheix G, Pereira B, Pickering GShort-Term Magnesium Therapy Alleviates Moderate Stress in Patients with Fibromyalgia: A Randomized Double-Blind Clinical Trial.Nutrients.(2022-May-17)
    33. Magnesium - Jaripur M, Ghasemi-Tehrani H, Askari G, Gholizadeh-Moghaddam M, Clark CCT, Rouhani MHThe effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.Reprod Biol Endocrinol.(2022-Aug-02)
    34. Melatonin - Chen KH, Zeng BY, Zeng BS, Sun CK, Cheng YS, Su KP, Wu YC, Chen TY, Lin PY, Liang CS, Hsu CW, Chu CS, Chen YW, Yeh PY, Wu MK, Tseng PT, Hsu CYThe efficacy of exogenous melatonin supplement in ameliorating irritable bowel syndrome severity: A meta-analysis of randomized controlled trials.J Formos Med Assoc.(2022-Oct-15)
    35. N-Acetylcysteine - Mohiuddin M, Pivetta B, Gilron I, Khan JSEfficacy and Safety of N-Acetylcysteine for the Management of Chronic Pain in Adults: A Systematic Review and Meta-Analysis.Pain Med.(2021-Dec-11)
    36. Yarrow - Zakeri S, Esmaeilzadeh S, Gorji N, Memariani Z, Moeini R, Bijani AThe effect of Achillea Millefolium L. on vulvovaginal candidiasis compared with clotrimazole: A randomized controlled trial.Complement Ther Med.(2020-Aug)
    37. Yarrow - Pirus Ghadjar, Wiebke Stritter, Irina von Mackensen, Felix Mehrhof, Clara Foucré, Vincent H Ehrhardt, Marcus Beck, Pimrapat Gebert, Goda Kalinauskaite, Jacqueline S Luchte, Carmen Stromberger, Volker Budach, Angelika Eggert, Georg SeifertExternal application of liver compresses to reduce fatigue in patients with metastatic cancer undergoing radiation therapy, a randomized clinical trialRadiat Oncol.(2021 Apr 19)
    38. Probiotics - Coffey MJ, Garg M, Homaira N, Jaffe A, Ooi CYProbiotics for people with cystic fibrosis.Cochrane Database Syst Rev.(2020-Jan-22)
    39. Fish Oil - Yu H, Su X, Lei T, Zhang C, Zhang M, Wang Y, Zhu L, Liu JEffect of Omega-3 Fatty Acids on Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Int J Chron Obstruct Pulmon Dis.(2021)
    40. Elderberry - Farahani AM, Aryanian Z, Memariani Z, Mozaffarpur SA, Shirafkan HA Comparison of the Effect of Topical Preparation of L. and Hydrocortisone on Hand Eczema: A Double-Blind Randomized Controlled Trial.J Altern Complement Med.(2021-Apr)
    41. Lavender - Roland von Känel, Siegfried Kasper, Guido Bondolfi, Edith Holsboer-Trachsler, Josef Hättenschwiler, Martin Hatzinger, Christian Imboden, Ellen Heitlinger, Erich SeifritzTherapeutic effects of Silexan on somatic symptoms and physical health in patients with anxiety disorders: A meta-analysisBrain Behav.(2021 Feb 27)
    42. Iron - Tomer Avni, Shelley Reich, Nirit Lev, Anat Gafter-GviliIron supplementation for restless legs syndrome - A systematic review and meta-analysisEur J Intern Med.(2019 May)
    43. Iron - Mei Z, Chen J, Luo S, Jin L, Liu Q, Chen YComparative efficacy of intravenous and oral iron supplements for the treatment of iron deficiency in patients with heart failure: A network meta-analysis of randomized controlled trials.Pharmacol Res.(2022-Aug)
    44. Mediterranean Diet - Limketkai BN, Godoy-Brewer G, Parian AM, Noorian S, Krishna M, Shah ND, White J, Mullin GEDietary Interventions for the Treatment of Inflammatory Bowel Diseases: An Updated Systematic Review and Meta-analysis.Clin Gastroenterol Hepatol.(2023-Sep)
    45. DHEA - Giovanni Corona, Giulia Rastrelli, Vito A Giagulli, Annamaria Sila, Alessandra Sforza, Gianni Forti, Edoardo Mannucci, Mario MaggiDehydroepiandrosterone supplementation in elderly men: a meta-analysis study of placebo-controlled trialsJ Clin Endocrinol Metab.(2013 Sep)
    46. Resveratrol - Joanna Giang, Xiao Lan, Megan Crichton, Wolfgang Marx, Skye MarshallEfficacy and safety of biophenol-rich nutraceuticals in adults with inflammatory gastrointestinal diseases or irritable bowel syndrome: A systematic literature review and meta-analysisNutr Diet.(2021 May 7)