In preclinical (animal and cell) studies, apigenin has exhibited effects on anxiety, neuroexcitation, and neurodegeneration.[1][2][3][4] In a mouse study, dosages of 3–10 mg/kg of body weight produced reductions in anxiety without causing sedation.[2] Neuroprotective effects, conferred through increased mitochondrial capacity, have also been observed in animal studies (1–33 μM).[4][1]
Few clinical studies translate these results into humans. Two of the most promising studies examined apigenin as a constituent of chamomile (Matricaria recutita) for anxiety and migraine. When participants with co-diagnoses of anxiety and depression were given 200–1,000 mg of chamomile extract per day for 8 weeks (standardized to 1.2% apigenin), researchers observed improvements in self-reported anxiety and depression scales.[5] In a similar cross-over trial, participants with migraine experienced a reduction in pain, nausea, vomiting, and light/noise sensitivity 30 minutes after application of a chamomile oleogel (0.233 mg/g of apigenin).[6]
References
- ^Jameie SB, Pirasteh A, Naseri A, Jameie MS, Farhadi M, Babaee JF, Elyasi Lβ-Amyloid Formation, Memory, and Learning Decline Following Long-term Ovariectomy and Its Inhibition by Systemic Administration of Apigenin and β-Estradiol.Basic Clin Neurosci.(2021)
- ^Viola H, Wasowski C, Levi de Stein M, Wolfman C, Silveira R, Dajas F, Medina JH, Paladini ACApigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects.Planta Med.(1995-Jun)
- ^Dourado NS, Souza CDS, de Almeida MMA, Bispo da Silva A, Dos Santos BL, Silva VDA, De Assis AM, da Silva JS, Souza DO, Costa MFD, Butt AM, Costa SLNeuroimmunomodulatory and Neuroprotective Effects of the Flavonoid Apigenin in Models of Neuroinflammation Associated With Alzheimer's Disease.Front Aging Neurosci.(2020)
- ^Silva B, Oliveira PJ, Dias A, Malva JOQuercetin, kaempferol and biapigenin from Hypericum perforatum are neuroprotective against excitotoxic insults.Neurotox Res.(2008)
- ^Amsterdam JD, Shults J, Soeller I, Mao JJ, Rockwell K, Newberg ABChamomile (Matricaria recutita) may provide antidepressant activity in anxious, depressed humans: an exploratory study.Altern Ther Health Med.(2012)
- ^Gaur K, Siddique YHEffect of apigenin on neurodegenerative diseases.CNS Neurol Disord Drug Targets.(2023-Apr-06)