1.
Sources and Composition
2.
Neurology
2.1
Aphrodisia
A 50% hydroalcoholic extract of syzygium aromaticum at 500mg/kg acutely is able to increase mounting of male mice with a potency nonsignificantly lesser than nutmeg (Myristica fragrans) and significantly less than 5mg/kg Viagra.[3] Later, oral intake of 100-500mg/kg of a 50% hydroalcoholic extract of syzygium aromaticum for seven days showed dose-dependent libido enhancement with a potency still lesser than 5mg/kg Viagra.[4]
Appears to have libido enhancing properties, although they are significantly less than that of Viagra and nonsignificantly less than the other libido enhancer tested (Nutmeg)
3.
Interactions with Organ Systems
3.1
Testicles (and male fertility)
Oral ingestion of 15mg/kg Syzygium aromaticum in male mice for 35 days is associated with increased testicular Δ5 3β-HSD and 17β-HSD enzyme activity (thought to underlie the observed increases in testosterone).[2]
30-60mg/kg dietary Syzygium aromaticum in male mice appears to induce testicular toxicity as assessed by serum testosterone and histological examination of the semineferous tubules.[2]
The essential oil of clove possesses spermicidal activity in vitro when incubated alongside the sperm[5] which may be related to the Eugenol content as this molecule has been known to possess anti-fertility actions.[6]
4.
Interactions with Hormones
4.1
Testosterone
Oral ingestion of an extract from the flower buds of Syzygium aromaticum at 15, 30, or 60mg/kg for 35 days in otherwise healthy male mice noted that the lowest dose of 15mg/kg increased serum testosterone 26% while the two higher doses were associated with reductions of testosterone (38-39%) secondary to testicular damage.[2]
References
- ^Domaracký M, Rehák P, Juhás S, Koppel JEffects of selected plant essential oils on the growth and development of mouse preimplantation embryos in vivoPhysiol Res.(2007)
- ^Mishra RK, Singh SKSafety assessment of Syzygium aromaticum flower bud (clove) extract with respect to testicular function in miceFood Chem Toxicol.(2008 Oct)
- ^Tajuddin, Ahmad S, Latif A, Qasmi IAAphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt. (nutmeg) and Syzygium aromaticum (L) Merr. & Perry. (clove) in male mice: a comparative studyBMC Complement Altern Med.(2003 Oct 20)
- ^Effect of 50% ethanolic extract of Syzygium aromaticum (L.) Merr. & Perry. (clove) on sexual behaviour of normal male rats
- ^Buch JG, Dikshit RK, Mansuri SMEffect of certain volatile oils on ejaculated human spermatozoaIndian J Med Res.(1988 Apr)
- ^Vanithakumari G, Sampathraj R, Selvaraj M, Thangamani REffect of short-term treatment of eugenol on the seminal vesicles of adult albino ratsIndian J Exp Biol.(1998 Dec)