Tetradecyl Thioacetic Acid

    Researchedby:
    Kamal Patel
    Last Updated: September 28, 2022

    Technically an Omega-3 fatty acid, TTA is a non-metabolizable fatty acid that cannot be used for energy and may be able to burn fat via mechanisms similar to Conjugated Linoleic Acid. Lacking studies in humans at the moment, TTA appears to be a promising future candidate for fat loss and health.

    examine-databaseExamine Database

    Tetradecyl Thioacetic Acid is most often used for .

    87 participants in 4 trials

    Summary

    Tetradecyl Thioacetic Acid, otherwise known as TTA, is what is known as a PPAR-alpha activator. It is actually an omega-3 fatty acid, but has a sulfur group at the omega-3 position; because of this addition it cannot be burnt for energy and thus has no relevant caloric value to humans.

    PPARa activation can be seen as protecting the body from excess fats (similar to PPARy activation). PPARa tends to clear fats from the blood into muscle or liver cells, and encourage them to be burnt for energy in these locations (by comparison, PPARy makes new fat cells for fats to reside in which minimizes their potential toxicity).

    The clearing of fat from the blood causes a drop in lipoproteins and a lowering of LDL cholesterol, and the burning of fats causes either fat burning or reduced fat gain. TTA can also decrease blood pressure and exert an anti-oxidant effect, the four mechanisms making it a cardioprotective compound.

    It is commonly used with the appetite suppressant oleoylethanolamide as a fat-burning combination.

    What are other names for Tetradecyl Thioacetic Acid

    Note that Tetradecyl Thioacetic Acid is also known as:
    • TTA

    Dosage information

    Not much evidence currently exists in human, but the standard dose appears to be 1g of TTA daily taken in divided dosages with meals.

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    Examine Database References

    1. Heart Rate - Reidar J Pettersen, Mohamed Salem, Jon Skorve, Rune J Ulvik, Rolf K Berge, Jan Erik NordrehaugPharmacology and safety of tetradecylthioacetic acid (TTA): phase-1 studyJ Cardiovasc Pharmacol.(2008 Apr)
    2. Weight - Løvås K, Røst TH, Skorve J, Ulvik RJ, Gudbrandsen OA, Bohov P, Wensaas AJ, Rustan AC, Berge RK, Husebye ESTetradecylthioacetic acid attenuates dyslipidaemia in male patients with type 2 diabetes mellitus, possibly by dual PPAR-alpha/delta activation and increased mitochondrial fatty acid oxidationDiabetes Obes Metab.(2009 Apr)
    3. HbA1c - Fredriksen J, Ueland T, Dyrøy E, Halvorsen B, Melby K, Melbye L, Skalhegg BS, Bohov P, Skorve J, Berge RK, Aukrust P, Frøland SSLipid-lowering and anti-inflammatory effects of tetradecylthioacetic acid in HIV-infected patients on highly active antiretroviral therapyEur J Clin Invest.(2004 Oct)
    4. Triglycerides - Morken T, Bohov P, Skorve J, Ulvik R, Aukrust P, Berge RK, Livden JKAnti-inflammatory and hypolipidemic effects of the modified fatty acid tetradecylthioacetic acid in psoriasis--a pilot studyScand J Clin Lab Invest.(2011 Jul)