Retinol binding protein 4 (RBP4) is a carrier protein that transports retinol (preformed vitamin A) in the blood from the liver to other tissues.[1] Single-nucleotide polymorphisms (variants) in the gene that codes for the RBP4 protein appear to be associated with retinol concentrations in the blood[2] and the risk of some conditions, including childhood obesity,[3] coronary artery disease,[4] insulin resistance,[5] gestational diabetes,[6] and type 2 diabetes.[7][8][9] The concentration of RBP4 protein in the blood has also been shown to be associated with the risk of gestational diabetes and type 2 diabetes.[10][11][12][13] However, while experiments using genetic mouse models support some of these associations,[1][14] further clinical studies are needed to fully understand whether RBP4 plays a causal role in human disease.
References
- ^Steinhoff JS, Lass A, Schupp MBiological Functions of RBP4 and Its Relevance for Human Diseases.Front Physiol.(2021)
- ^Alison M Mondul, Kai Yu, William Wheeler, Hong Zhang, Stephanie J Weinstein, Jacqueline M Major, Marilyn C Cornelis, Satu Männistö, Aditi Hazra, Ann W Hsing, Kevin B Jacobs, Heather Eliassen, Toshiko Tanaka, Douglas J Reding, Sara Hendrickson, Luigi Ferrucci, Jarmo Virtamo, David J Hunter, Stephen J Chanock, Peter Kraft, Demetrius AlbanesGenome-wide association study of circulating retinol levelsHum Mol Genet.(2011 Dec 1)
- ^Pilar Codoñer-Franch, Joaquín Carrasco-Luna, Paula Allepuz, Alan Codoñer-Alejos, Vicent GuillemAssociation of RBP4 genetic variants with childhood obesity and cardiovascular risk factorsPediatr Diabetes.(2016 Dec)
- ^Wan K, Zhao J, Deng Y, Chen X, Zhang Q, Zeng Z, Zhang L, Chen YA genetic polymorphism in RBP4 is associated with coronary artery disease.Int J Mol Sci.(2014-Dec-03)
- ^Kovacs P, Geyer M, Berndt J, Klöting N, Graham TE, Böttcher Y, Enigk B, Tönjes A, Schleinitz D, Schön MR, Kahn BB, Blüher M, Stumvoll MEffects of genetic variation in the human retinol binding protein-4 gene (RBP4) on insulin resistance and fat depot-specific mRNA expression.Diabetes.(2007-Dec)
- ^Hu S, Ma S, Li X, Tian Z, Liang H, Yan J, Chen M, Tan HRelationships of , , and Gene Polymorphisms with Gestational Diabetes Mellitus in a Chinese Population.Biomed Res Int.(2019)
- ^Craig RL, Chu WS, Elbein SCRetinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intermediate traits.Mol Genet Metab.(2007-Mar)
- ^Munkhtulga L, Nakayama K, Utsumi N, Yanagisawa Y, Gotoh T, Omi T, Kumada M, Erdenebulgan B, Zolzaya K, Lkhagvasuren T, Iwamoto SIdentification of a regulatory SNP in the retinol binding protein 4 gene associated with type 2 diabetes in Mongolia.Hum Genet.(2007-Feb)
- ^van Hoek M, Dehghan A, Zillikens MC, Hofman A, Witteman JC, Sijbrands EJAn RBP4 promoter polymorphism increases risk of type 2 diabetes.Diabetologia.(2008-Aug)
- ^Hu S, Liu Q, Huang X, Tan HSerum level and polymorphisms of retinol-binding protein-4 and risk for gestational diabetes mellitus: a meta-analysis.BMC Pregnancy Childbirth.(2016-Mar-14)
- ^Huang QT, Huang Q, Luo W, Li F, Hang LL, Yu YH, Zhong MCirculating retinol-binding protein 4 levels in gestational diabetes mellitus: a meta-analysis of observational studies.Gynecol Endocrinol.(2015-May)
- ^Tan X, Zhang H, Liu L, Yu Z, Liu X, Cui L, Chen Y, Zhang H, Gao Z, Zhao ZThe association between retinol-binding protein 4 and risk of type 2 diabetes: A systematic review and meta-analysis.Int J Environ Health Res.(2023-Mar-29)
- ^Olsen T, Blomhoff RRetinol, Retinoic Acid, and Retinol-Binding Protein 4 are Differentially Associated with Cardiovascular Disease, Type 2 Diabetes, and Obesity: An Overview of Human Studies.Adv Nutr.(2020-May-01)
- ^Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L, Kahn BBSerum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes.Nature.(2005-Jul-21)